Synthetic versions of the natural hormone produced by your body have been designed to prepare or ‘ripen’ the cervix for labour but they can also sometimes start labour. They can be administered as a gel or pessary that is inserted into your vagina during a vaginal examination. A pessary slowly releases the prostaglandin over 12–24 hours and the gel is usually given every 6-8 hours. Several doses may be required to induce labour. Once the prostaglandin is in place, you will be advised to lie down and rest for at least 30 minutes and your baby’s heart rate will be monitored during this time. The advantages are that inducing labour with prostaglandins may mimic normal labour and allow you to resume active birthing once the period of monitoring indicates all is well. Sometimes prostaglandins can cause side-effects such as nausea, vomiting or diarrhoea, local allergic reactions and occasionally they can cause the uterus to over contract (tonic or hypertonic contractions), with little rest in between. Overstimulation of the uterus may reduce oxygenation to the baby and cause its heart rate to slow. If this occurs you will be asked to lie on your left side and the prostaglandin may need to be removed or you may be given another medication to relax the uterus. You should inform your midwife immediately if you experience any of the following:
- Painful contractions
- Your membranes rupture (your waters break) spontaneously
- Your baby seems to be moving more or less than usual
- You have vaginal bleeding
If the prostaglandins have not started labour, it is usual to require additional methods of induction or to wait and try again at a later date, depending on your particular circumstances.